PT  - JOURNAL ARTICLE
AU  - Timmer, Monique H M
AU  - van Beek, Maria H C T
AU  - Bloem, Bas R
AU  - Esselink, Rianne A J
TI  - What a neurologist should know about depression in Parkinson’s disease
AID  - 10.1136/practneurol-2017-001650
DP  - 2017 Oct 01
TA  - Practical Neurology
PG  - 359--368
VI  - 17
IP  - 5
4099  - http://pn.bmj.com/content/17/5/359.short
4100  - http://pn.bmj.com/content/17/5/359.full
SO  - Pract Neurol2017 Oct 01; 17
AB  - Depression is a frequent non-motor symptom of Parkinson’s disease. Its prevalence varies widely across studies (between 2.7% and 90%); around 35% have clinically significant depressive symptoms. Although depression can have an immense impact on the quality of life of affected patients and their caregivers, depressive symptoms in Parkinson’s disease frequently remain unrecognised and, as a result, remain untreated. Here we overview the diagnostic challenges and pitfalls, including the factors contributing to the underdiagnosis of depression. We also discuss current ideas on the underlying pathophysiology. Finally, we offer a treatment approach based on currently available evidence.