RT Journal Article
SR Electronic
T1 Lupus myelopathy
JF Practical Neurology
JO Pract Neurol
FD BMJ Publishing Group Ltd
SP 66
OP 69
DO 10.1136/practneurol-2017-001756
VO 18
IS 1
A1 Raciborska, Dominika D
A1 Noyce, Alastair John
A1 Pyne, Dev
A1 Turner, Benjamin P
YR 2018
UL http://pn.bmj.com/content/18/1/66.abstract
AB Although neurological manifestations of systemic lupus erythematosus (SLE) are well recognised, myelopathy complicating SLE is rare. A 35-year-old woman presented with non-specific symptoms and a respiratory tract infection but had serological evidence of SLE. She subsequently deteriorated rapidly, developing a catastrophic spinal cord syndrome. Her initial MRI was normal; but after 1 month, her encephalopathy having progressed, repeat imaging showed characteristic myelitic changes. She responded only slowly to a combination of cyclophosphamide and corticosteroids. This case exemplifies the mixed presentations of SLE, including the under-recognised ‘subpial leukomyelopathy’ of central nervous system lupus. It highlights the challenges in managing lupus-related myelopathy and the benefits of a multidisciplinary approach to care.