RT Journal Article SR Electronic T1 Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis JF Practical Neurology JO Pract Neurol FD BMJ Publishing Group Ltd SP practneurol-2017-001863 DO 10.1136/practneurol-2017-001863 A1 Angeliki Zarkali A1 Oliver Cousins A1 Dilan Athauda A1 Samuel Moses A1 Nicholas Moran A1 Sreedharan Harikrishnan YR 2018 UL http://pn.bmj.com/content/early/2018/02/08/practneurol-2017-001863.abstract AB Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis is a newly described, possibly under-recognised, severe inflammatory condition of the nervous system. The clinical presentation is variable but most commonly is a combination of meningitis, encephalitis and myelitis; other manifestations may include seizures, psychiatric symptoms and tremor. There is a significant association with malignancies, often occult, and with other autoimmune conditions. Although the disease responds well to corticosteroids acutely, it typically relapses when these are tapered, and so patients need long-term immunosuppression. We report a young man presenting with subacute meningoencephalitis and subsequent myelitis, and discuss the typical presentation and management of this severe but treatable condition.