RT Journal Article SR Electronic T1 A practical approach to the diagnosis of spinal cord lesions JF Practical Neurology JO Pract Neurol FD BMJ Publishing Group Ltd SP practneurol-2017-001845 DO 10.1136/practneurol-2017-001845 A1 Romina Mariano A1 Eoin P Flanagan A1 Brain G Weinshenker A1 Jacqueline Palace YR 2018 UL http://pn.bmj.com/content/early/2018/03/02/practneurol-2017-001845.abstract AB Every neurologist will be familiar with the patient with atypical spinal cord disease and the challenges of taking the diagnosis forward. This is predominantly because of the limited range of possible clinical and investigation findings making most individual features non-specific. The difficulty in obtaining a tissue diagnosis further contributes and patients are often treated empirically based on local prevalence and potential for reversibility. This article focuses on improving the diagnosis of adult non-traumatic, non-compressive spinal cord disorders. It is structured to start with the clinical presentation in order to be of practical use to the clinician. We aim, by combining the onset phenotype with the subsequent course, along with imaging and laboratory features, to improve the diagnostic process.