TY - JOUR T1 - Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia JF - Practical Neurology JO - Pract Neurol SP - 166 LP - 169 DO - 10.1136/practneurol-2017-001800 VL - 18 IS - 2 AU - Samuel Shribman AU - Alastair Noyce AU - Sharmilee Gnanapavan AU - Jonathan Lambourne AU - Thomas Harrison AU - Frederick Schon Y1 - 2018/04/01 UR - http://pn.bmj.com/content/18/2/166.abstract N2 - We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%–27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis. ER -