PT  - JOURNAL ARTICLE
AU  - Samuel Shribman
AU  - Alastair Noyce
AU  - Sharmilee Gnanapavan
AU  - Jonathan Lambourne
AU  - Thomas Harrison
AU  - Frederick Schon
TI  - Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia
AID  - 10.1136/practneurol-2017-001800
DP  - 2018 Apr 01
TA  - Practical Neurology
PG  - 166--169
VI  - 18
IP  - 2
4099  - http://pn.bmj.com/content/18/2/166.short
4100  - http://pn.bmj.com/content/18/2/166.full
SO  - Pract Neurol2018 Apr 01; 18
AB  - We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%–27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis.