PT - JOURNAL ARTICLE AU - Rhys H Thomas AU - Mark O Cunningham TI - Cannabis and epilepsy AID - 10.1136/practneurol-2018-002058 DP - 2018 Dec 01 TA - Practical Neurology PG - 465--471 VI - 18 IP - 6 4099 - http://pn.bmj.com/content/18/6/465.short 4100 - http://pn.bmj.com/content/18/6/465.full SO - Pract Neurol2018 Dec 01; 18 AB - Click here to listen to the Podcast The one-third of people who do not gain seizure control through current treatment options need a revolution in epilepsy therapeutics. The general population appears to be showing a fundamental and rapid shift in its opinion regarding cannabis and cannabis-related drugs. It is quite possible that cannabidiol, licensed in the USA for treating rare genetic epilepsies, may open the door for the widespread legalisation of recreational cannabis. It is important that neurologists understand the difference between artisanal cannabidiol products available legally on the high street and the cannabidiol medications that have strong trial evidence. In the UK in 2018 there are multiple high-profile reports of the response of children taking cannabis-derived medication, meaning that neurologists are commonly asked questions about these treatments in clinic. We address what an adult neurologist needs to know now, ahead of the likely licensing of Epidiolex in the UK in 2019.