PT  - JOURNAL ARTICLE
AU  - Harris, Matthew John
AU  - Cossburn, Mark Daniel
AU  - Pengas, George
TI  - Multiple cerebral infarcts: a rare complication of neurosarcoidosis
AID  - 10.1136/practneurol-2018-002133
DP  - 2019 Jun 01
TA  - Practical Neurology
PG  - 246--249
VI  - 19
IP  - 3
4099  - http://pn.bmj.com/content/19/3/246.short
4100  - http://pn.bmj.com/content/19/3/246.full
SO  - Pract Neurol2019 Jun 01; 19
AB  - A 52-year-old man experienced a relapse of neurosarcoidosis, characterised by obstructive hydrocephalus and multiple posterior circulation infarcts. He was taking methotrexate, but his prednisolone was being weaned because of adverse effects. Stroke is rare in neurosarcoidosis and typically relates to granulomatous inflammation with a predilection for the perforator arteries. Sarcoidosis generally responds well to corticosteroids; however, patients with leptomeningeal involvement usually require additional immunosuppression as relapses can occur on weaning of corticosteroids. It is worth considering tumour necrosis factor-α antagonists for cases that progress despite first-line therapy.