RT Journal Article SR Electronic T1 Multiple cerebral infarcts: a rare complication of neurosarcoidosis JF Practical Neurology JO Pract Neurol FD BMJ Publishing Group Ltd SP 246 OP 249 DO 10.1136/practneurol-2018-002133 VO 19 IS 3 A1 Matthew John Harris A1 Mark Daniel Cossburn A1 George Pengas YR 2019 UL http://pn.bmj.com/content/19/3/246.abstract AB A 52-year-old man experienced a relapse of neurosarcoidosis, characterised by obstructive hydrocephalus and multiple posterior circulation infarcts. He was taking methotrexate, but his prednisolone was being weaned because of adverse effects. Stroke is rare in neurosarcoidosis and typically relates to granulomatous inflammation with a predilection for the perforator arteries. Sarcoidosis generally responds well to corticosteroids; however, patients with leptomeningeal involvement usually require additional immunosuppression as relapses can occur on weaning of corticosteroids. It is worth considering tumour necrosis factor-α antagonists for cases that progress despite first-line therapy.