TY - JOUR T1 - Finger extension weakness and downbeat nystagmus motor neurone disease (FEWDON-MND) JF - Practical Neurology JO - Pract Neurol SP - 424 LP - 426 DO - 10.1136/practneurol-2018-002188 VL - 19 IS - 5 AU - Wladimir B V R Pinto AU - Igor Braga Farias AU - Bruno de Mattos Lombardi Badia AU - Luiz Henrique Libardi Silva AU - Mario Teruo Yanagiura AU - Marco Antônio Troccoli Chieia AU - Paulo Victor Sgobbi de Souza AU - Acary Souza Bulle Oliveira Y1 - 2019/10/01 UR - http://pn.bmj.com/content/19/5/424.abstract N2 - Atypical motor neurone disease (MND) represents a challenging and expanding group of neurodegenerative disorders involving the upper or lower motor neurones, and rarely both. Neuro-ophthalmological disturbances such as gaze-evoked downbeat nystagmus are extremely rare in the context of typical and atypical MND. Finger extension weakness and downbeat nystagmus motor neurone disease (FEWDON-MND) syndrome has been recently recognised as a distinct syndromic phenotype of MND, with a characteristic clinical picture. We describe a 63-year-old woman with long-standing lower motor neurone involvement of the upper limbs, who on examination had gaze-evoked downbeat nystagmus. After extensive negative investigation for secondary causes of MND and downbeat nystagmus, we diagnosed FEWDON-MND syndrome. ER -