PT - JOURNAL ARTICLE AU - Reyes, Saúl AU - Ramsay, Mary AU - Ladhani, Shamez AU - Amirthalingam, Gayatri AU - Singh, Neena AU - Cores, Carlos AU - Mathews, joela AU - Lambourne, Jonathan AU - Marta, Monica AU - Turner, Benjamin AU - Gnanapavan, Sharmilee AU - Dobson, Ruth AU - Schmierer, Klaus AU - Giovannoni, G TI - Protecting people with multiple sclerosis through vaccination AID - 10.1136/practneurol-2020-002527 DP - 2020 Dec 01 TA - Practical Neurology PG - 435--445 VI - 20 IP - 6 4099 - http://pn.bmj.com/content/20/6/435.1.short 4100 - http://pn.bmj.com/content/20/6/435.1.full SO - Pract Neurol2020 Dec 01; 20 AB - Vaccination is one of the most effective and cost-efficient methods for protecting people with multiple sclerosis (MS) from infections. However, use of vaccines has often been problematic because of misguided concerns that they may exacerbate the disease and/or that some disease-modifying therapies may influence the immune response to immunisations and/or their safety. People with MS risk higher morbidity and mortality from vaccine-preventable infections. It is, therefore, important to address any patient’s reluctance to accept vaccination and to provide clear guidance for clinicians on which vaccinations to consider proactively. We have reviewed the current literature and provide recommendations regarding vaccines in adults with MS, including specific advice regarding vaccination safety in patients receiving—or going to receive—disease-modifying therapies, vaccination during pregnancy, pretravel counselling and patient education.