TY - JOUR T1 - Carphology JF - Practical Neurology JO - Pract Neurol SP - 270 LP - 270 DO - 10.1136/practneurol-2021-003065 VL - 21 IS - 3 AU - A Fo Ben Y1 - 2021/06/01 UR - http://pn.bmj.com/content/21/3/270.abstract N2 - Typically, you wait 14 years for a follow-up for the seminal SANAD study and then two open-label, non-inferiority, multicentre, phase IV, randomised controlled trials come along at once.Children and adults with focal epilepsy were randomised (1:1:1) to lamotrigine, levetiracetam or zonisamide for initial monotherapy. Patients were followed up for 2.0–7.5 years. At 2 years, 5% fewer participants had a remission on levetiracetam compared with lamotrigine. Lamotrigine was also better tolerated; compared with lamotrigine, there were 16% more treatment failures on levetiracetam and 23% more treatment failures on zonisamide at 2 years; the majority of these were due to adverse effects. This means that, despite the slower titration of lamotrigine, the median time to 12-month … ER -