TY - JOUR T1 - Toluene-induced leukodystrophy from glue sniffing JF - Practical Neurology JO - Pract Neurol DO - 10.1136/practneurol-2021-002942 SP - practneurol-2021-002942 AU - Yue Hui Lau AU - Ahmad Shahir Mawardi AU - Norzaini Rose Zain AU - Shanthi Viswanathan Y1 - 2021/05/26 UR - http://pn.bmj.com/content/early/2021/05/26/practneurol-2021-002942.abstract N2 - A 33-year-old man with a history of chronic toluene abuse through glue sniffing, developed tremors, cerebellar signs and cognitive decline. MR scan of the brain showed global cerebral and cerebellar atrophy with symmetrical T2-weighted hypointensities in the basal ganglia, thalami and midbrain. After stopping glue sniffing, his tremors, ataxia of gait, speech and cognition partially improved. Early recognition and intervention of toluene-induced leukodystrophy could prevent ongoing morbidity and premature mortality. ER -