TY - JOUR T1 - Allodynia, rigidity and gait disturbance JF - Practical Neurology JO - Pract Neurol SP - 363 LP - 366 DO - 10.1136/practneurol-2020-002669 VL - 21 IS - 4 AU - Mariano Ruiz-Ortiz AU - Mario Díaz-Santiáñez AU - F Javier Azcárate-Díaz AU - Juan Francisco Gonzalo-Martínez AU - Sara Moreno-García AU - Raquel Ruiz-García AU - Patricia Calleja-Castaño Y1 - 2021/08/01 UR - http://pn.bmj.com/content/21/4/363.abstract N2 - A 57-year-old woman presented with gait disturbance and falls. Two months before, she had first developed stiffness and painful spasms in her lower back and thighs. These sy7mptoms had worsened on trying to stand or walk, persisted while sleeping and progressed. She had no weakness, sensory loss or sphincter disturbance. There was no apparent infective trigger, no fever, weight loss, or other systemic symptoms. Over the previous year, she had been assessed for fatigue, dyspareunia, anxiety and insomnia. She smoked 10 cigarettes a day.On examination, her mental status and cranial nerves were normal. She had normal muscle strength in all groups but there was axial and proximal stiffness in lower limbs, with spasms and delayed muscle relaxation after voluntary activation; the right leg was more affected than the left. Reflexes were globally exaggerated with both plantar responses flexor. There was no myotonia, fasciculation or other signs of spontaneous muscle activity. Extrapyramidal and cerebellar tests were normal. She reported mild allodynia wherever her body was rubbed, but there was no objective deficit or any sensory modality. Her gait was unstable with slow steps, extended legs, broad base, lumbar hyperlordosis and poor girdle swing.This patient had a subacute-progressive gait disturbance due to axial and proximal lower limbs stiffness, associated with painful spasms and non-specific sensory symptoms. Her possible diagnoses (ordered by topography) included1 2:Muscle and neuromuscular junctionThis seems unlikely as it does not explain the sensory symptoms, and myotonic syndromes do not have such a subacute course.Peripheral nerveWith predominantly positive symptoms, we need to consider continuous muscular activity disorders such as neuromyotonia (Isaacs and Morvan syndromes; Morvan may present with sleep disorders but usually in the context of a progressive encephalopathy), cramp–fasciculation syndrome and Satoyoshi syndrome (very rare, it can occur in adults accompanied by baldness and diarrhoea, which this … ER -