TY - JOUR T1 - Cushing’s disease presenting with psychosis JF - Practical Neurology JO - Pract Neurol SP - 351 LP - 353 DO - 10.1136/practneurol-2021-002974 VL - 21 IS - 4 AU - Ahmed Saeed Mubarak Mohamed AU - Ahmed Iqbal AU - Suveera Prasad AU - Nigel Hoggard AU - Daniel Blackburn Y1 - 2021/08/01 UR - http://pn.bmj.com/content/21/4/351.abstract N2 - Cushing’s disease is a rare endocrine condition in which a pituitary corticotroph adenoma drives excess adrenal cortisol production, and is one cause of endogenous Cushing’s syndrome. We present a young woman with 3 weeks of headaches and cognitive disturbance who subsequently developed florid psychosis requiring multiple admissions under neurology and psychiatry. Her clinical stigmata of hypercortisolism and biochemical abnormalities prompted an MR scan of the pituitary, which confirmed a pituitary microadenoma. Treatment with metyrapone and subsequent surgery led to complete recovery within 2 months. Cushing’s disease commonly causes neuropsychiatric symptoms and can present with psychosis. Diagnosing Cushing’s disease can be challenging, but with early diagnosis and treatment it has an excellent prognosis. ER -