RT Journal Article
SR Electronic
T1 Posterior reversible encephalopathy syndrome (PRES): diagnosis and management
JF Practical Neurology
JO Pract Neurol
FD BMJ Publishing Group Ltd
SP 183
OP 189
DO 10.1136/practneurol-2021-003194
VO 22
IS 3
A1 Triplett, James D
A1 Kutlubaev, Mansur Amirovich
A1 Kermode, Allan G
A1 Hardy, Todd
YR 2022
UL http://pn.bmj.com/content/22/3/183.abstract
AB Posterior reversible encephalopathy syndrome (PRES) may present with diverse clinical symptoms including visual disturbance, headache, seizures and impaired consciousness. MRI shows oedema, usually involving the posterior subcortical regions. Triggering factors include hypertension, pre-eclampsia/eclampsia, renal failure, cytotoxic agents and autoimmune conditions. The mechanism underlying PRES is not certain, but endothelial dysfunction is implicated. Treatment is supportive and involves correcting the underlying cause and managing associated complications, such as seizures. Although most patients recover, PRES is not always reversible and may be associated with considerable morbidity and even mortality.