TY - JOUR T1 - Primary progressive aphasia: ReADing the clinical GRANularity JF - Practical Neurology JO - Pract Neurol DO - 10.1136/practneurol-2022-003460 SP - practneurol-2022-003460 AU - Anthipa Chokesuwattanaskul AU - Charles R Marshall AU - Natasja van Harskamp AU - Henry Houlden AU - Jonathan Rohrer AU - Chris JD Hardy AU - Jason D Warren Y1 - 2022/06/16 UR - http://pn.bmj.com/content/early/2022/06/15/practneurol-2022-003460.abstract N2 - Primary progressive aphasia remains a diagnostic challenge despite (or even because of) the increasing availability of ancillary tests and biomarkers. We present a 67-year-old man with apparently sporadic logopenic aphasia and positive Alzheimer biomarkers who was subsequently found also to have a pathogenic mutation in the progranulin gene. This was signalled by early atypical features (mild expressive agrammatism and behavioural change, rapid clinical deterioration) around the core logopenic aphasia syndrome. Each of the canonical progressive aphasia syndromes has a ‘halo’ of less typical variants that may herald alternative or additional pathologies. The accurate diagnosis of primary progressive aphasia depends on careful clinical analysis to direct investigations appropriately.Data are available upon reasonable request to the corresponding author. ER -