PT  - JOURNAL ARTICLE
AU  - Nikhil Dongre
AU  - Varsha Ambwani
AU  - Vinita Elizabeth Mani
AU  - Vimal Kumar Paliwal
TI  - Alien-hand syndrome with mirror movements in hereditary diffuse leukoencephalopathy with spheroids
AID  - 10.1136/practneurol-2021-003237
DP  - 2022 Aug 01
TA  - Practical Neurology
PG  - 321--323
VI  - 22
IP  - 4
4099  - http://pn.bmj.com/content/22/4/321.short
4100  - http://pn.bmj.com/content/22/4/321.full
SO  - Pract Neurol2022 Aug 01; 22
AB  - Hereditary diffuse leukoencephalopathy with spheroids is a rare genetic disorder caused by mutations of the colony-stimulating factor 1 receptor gene. It is an adult-onset leukodystrophy, with a wide spectrum of neurological and psychiatric manifestations that includes Parkinsonism, dementia, seizures, limb weakness, spasticity and abnormal motor behaviour. Alien-hand syndrome and mirror movements are rare manifestations of this and other neurodegenerative disorders. We describe a woman with progressive limb and trunk rigidity, Parkinsonism and dementia, who also had involuntary left arm levitation (part of the posterior variant of alien-hand syndrome) and left-hand mirror movements. We discuss the different types of alien-hand syndrome, and the likely mechanisms of arm levitation and mirror movements.