TY - JOUR T1 - Cerebrovascular disease in sickle cell disease JF - Practical Neurology JO - Pract Neurol DO - 10.1136/pn-2022-003440 SP - practneurol-2022-003440 AU - Vafa Alakbarzade AU - Chinedu Maduakor AU - Usman Khan AU - Nader Khandanpour AU - Elizabeth Rhodes AU - Anthony C Pereira Y1 - 2022/09/19 UR - http://pn.bmj.com/content/early/2022/09/19/pn-2022-003440.abstract N2 - Sickle cell disease (SCD) is the most common type of hereditary anaemia and genetic disorder worldwide. Cerebrovascular disease is one of its most devastating complications, with consequent increased morbidity and mortality. Current guidelines suggest that children and adults with SCD who develop acute ischaemic stroke should be transfused without delay. Those with acute ischaemic stroke aged over 18 years who present within 4.5 hours of symptom onset should be considered for intravenous thrombolysis; older patients with conventional vascular risk factors are the most likely to benefit. Endovascular thrombectomy should be considered carefully in adults with SCD as there are few data to guide how the prevalence of cerebral vasculopathy may confound the expected benefits or risks of intervention. We present a practical approach to cerebrovascular disease in sickle cell patients based on the available evidence and our experience.Data are available upon reasonable request. ER -