PT - JOURNAL ARTICLE AU - Patrick W Cullinane AU - Katie Sidle AU - Kailash P Bhatia AU - Tamas Revesz AU - Thomas T Warner TI - Globular glial tauopathy type II AID - 10.1136/pn-2022-003549 DP - 2022 Nov 21 TA - Practical Neurology PG - pn-2022-003549 4099 - http://pn.bmj.com/content/early/2022/11/21/pn-2022-003549.short 4100 - http://pn.bmj.com/content/early/2022/11/21/pn-2022-003549.full AB - The globular glial tauopathies (GGTs) are a rare group of neurodegenerative diseases with fewer than 90 autopsy-confirmed cases reported in the literature. Although there has been some uncertainty about whether GGT is entirely distinct from progressive supranuclear palsy, a recent study of tau filament structures supports the definition of GGT as a separate neuropathological entity. We present a sporadic case of GGT type II presenting with a progressive corticobasal–primary lateral sclerosis overlap syndrome in a 74-year-old woman. Neuropathological examination identified neuronal and glial tau inclusions, including globular astrocytic and oligodendroglial inclusions. We also discuss the clinical features and molecular pathophysiology of GGT. Increased awareness of this condition could become more important as patients with GGT may be candidates for anti-tau therapies currently undergoing clinical evaluation in patients with other tauopathies.Data sharing not applicable as no datasets generated and/or analysed for this study.