RT Journal Article
SR Electronic
T1 Globular glial tauopathy type II
JF Practical Neurology
JO Pract Neurol
FD BMJ Publishing Group Ltd
SP pn-2022-003549
DO 10.1136/pn-2022-003549
A1 Patrick W Cullinane
A1 Katie Sidle
A1 Kailash P Bhatia
A1 Tamas Revesz
A1 Thomas T Warner
YR 2022
UL http://pn.bmj.com/content/early/2022/11/21/pn-2022-003549.abstract
AB The globular glial tauopathies (GGTs) are a rare group of neurodegenerative diseases with fewer than 90 autopsy-confirmed cases reported in the literature. Although there has been some uncertainty about whether GGT is entirely distinct from progressive supranuclear palsy, a recent study of tau filament structures supports the definition of GGT as a separate neuropathological entity. We present a sporadic case of GGT type II presenting with a progressive corticobasal–primary lateral sclerosis overlap syndrome in a 74-year-old woman. Neuropathological examination identified neuronal and glial tau inclusions, including globular astrocytic and oligodendroglial inclusions. We also discuss the clinical features and molecular pathophysiology of GGT. Increased awareness of this condition could become more important as patients with GGT may be candidates for anti-tau therapies currently undergoing clinical evaluation in patients with other tauopathies.Data sharing not applicable as no datasets generated and/or analysed for this study.