@article {Nasirpn-2022-003560, author = {Memoona Nasir and Ruth Obrocki and Magdalini Krommyda and Naveed Malek}, title = {Conus medullaris syndrome as a presenting feature of MOG-associated disease}, elocation-id = {pn-2022-003560}, year = {2023}, doi = {10.1136/pn-2022-003560}, publisher = {BMJ Publishing Group Ltd}, abstract = {We report a case of conus medullaris syndrome presenting with lower limb and bladder symptoms. MR imaging showed an abnormality in the lowest part of the spinal cord as a first presentation of myelin oligodendrocyte glycoprotein (MOG)-associated disease. While such cord swelling can mimic a tumour, these patients respond well to corticosteroids, with good outcomes. MOG-associated disease is an immune-mediated syndrome distinct from aquaporin 4 antibody positive neuromyelitis optica syndrome and is now considered an independent entity. Although there can be overlapping phenotypes, there are also differences, and MOG-associated disease generally has a much better prognosis compared with aquaporin 4 antibody-positive neuromyelitis optica syndrome.All data relevant to the study are included in the article or uploaded as online supplemental information. Not Applicable.}, issn = {1474-7758}, URL = {https://pn.bmj.com/content/early/2023/01/13/pn-2022-003560}, eprint = {https://pn.bmj.com/content/early/2023/01/13/pn-2022-003560.full.pdf}, journal = {Practical Neurology} }