PT  - JOURNAL ARTICLE
AU  - Memoona Nasir
AU  - Ruth Obrocki
AU  - Magdalini Krommyda
AU  - Naveed Malek
TI  - Conus medullaris syndrome as a presenting feature of MOG-associated disease
AID  - 10.1136/pn-2022-003560
DP  - 2023 Jan 13
TA  - Practical Neurology
PG  - pn-2022-003560
4099  - http://pn.bmj.com/content/early/2023/01/13/pn-2022-003560.short
4100  - http://pn.bmj.com/content/early/2023/01/13/pn-2022-003560.full
AB  - We report a case of conus medullaris syndrome presenting with lower limb and bladder symptoms. MR imaging showed an abnormality in the lowest part of the spinal cord as a first presentation of myelin oligodendrocyte glycoprotein (MOG)-associated disease. While such cord swelling can mimic a tumour, these patients respond well to corticosteroids, with good outcomes. MOG-associated disease is an immune-mediated syndrome distinct from aquaporin 4 antibody positive neuromyelitis optica syndrome and is now considered an independent entity. Although there can be overlapping phenotypes, there are also differences, and MOG-associated disease generally has a much better prognosis compared with aquaporin 4 antibody-positive neuromyelitis optica syndrome.All data relevant to the study are included in the article or uploaded as online supplemental information. Not Applicable.