PT  - JOURNAL ARTICLE
AU  - Duncan Smyth
AU  - Caroline Kramarz
AU  - Aisling S Carr
AU  - Alexander M Rossor
AU  - Michael P Lunn
TI  - Toxic neuropathies: a practical approach
AID  - 10.1136/pn-2022-003444
DP  - 2023 Apr 01
TA  - Practical Neurology
PG  - 120--130
VI  - 23
IP  - 2
4099  - http://pn.bmj.com/content/23/2/120.short
4100  - http://pn.bmj.com/content/23/2/120.full
SO  - Pract Neurol2023 Apr 01; 23
AB  - Toxic neuropathies result from exogenous substances damaging the peripheral nerves. There are numerous causes, including prescribed and recreational drugs, heavy metals, industrial agents and biological toxins. Timely recognition of these neuropathies gives better outcomes, as they usually improve or stabilise once the toxin is removed. Most toxic neuropathies are axonal, length-dependent and sensory predominant, although some have significant motor involvement or can present acutely or subacutely. Here, we outline our clinical approach and discuss the major causes of toxic neuropathy, while emphasising the clinical and neurophysiological features and the neuropathy phenotype. We also include an update on newer medications that can cause neuropathy, including immune checkpoint inhibitors and BRAF/MEK inhibitors.Data sharing not applicable as no datasets generated and/or analysed for this study.