Recurring migraine that significantly interferes with quality of life and the patient’s daily routine, despite acute treatment of the attacks

Frequency of migraine attacks ⩾1/week

Frequency of acute headache medication use ⩾2 days/week

Failure of, contraindication to, or troublesome adverse effects from acute medication

Presence of uncommon migraine conditions, including hemiplegic migraine, basilar migraine, migraine with prolonged, disabling or frequent aura, or migrainous cerebral infarction