Definite: clinical presentation suggestive of neurosarcoidosis + positive nervous system histology + exclusion of other possible diagnoses (ie, sarcoid mimics) |
Probable: clinical presentation suggestive of neurosarcoidosis + laboratory support for CNS inflammation (raised CSF protein +/− cells, oligoclonal bands and/or CSF CD4:CD8 ratio >5 and/or MRI evidence compatible with neurosarcoidosis) + exclusion of alternative diagnoses +/− evidence of systemic sarcoidosis (either by positive histology, and/or at least 2 indirect indicators from gallium scan, high definition CT of the chest, bronchoalveolar lavage with CD4:CD8 ratio >3.5) |
Possible: clinical presentation suggestive of neurosarcoidosis with exclusion of alternative diagnoses where above criteria are not met |