Distinguishing between multiple sclerosis and neurosarcoidosis: in favour of neurosarcoidosis
| Systemic features | May be already present, or appear later in the course of the disease |
| Neurological features | Most common are cranial neuropathies (especially lower motor neuron facial weakness), seizures, meningitis, and effects of mass lesions |
| MRI brain | Leptomeningeal enhancement with gadolinium, mass lesions (but periventricular lesions may also occur) |
| CSF | Often significant protein elevation (>2 g/l), mild lymphocytosis. CSF oligoclonal bands may be seen, but generally associated with CSF protein elevation |
| Systemic investigations | Serum ACE, ESR, and calcium may be elevated; CXR, CT thorax, gallium scan, and systemic tissue biopsy may be positive |