Criteria for dementia unlikely to be due to AD
| (1) Does not meet clinical criteria for AD dementia |
| (2) Regardless of meeting clinical criteria for probable or possible AD dementia |
| a. There is sufficient evidence for an alternative diagnosis such as HIV dementia, dementia of Huntington's disease or others that rarely overlap with AD |
| b. Biomarkers for both Aβ and neuronal degeneration are negative |
Aβ, amyloid β; AD, Alzheimer's disease. Adapted from McKhann et al.7