(1) Markers of amyloid-β (Aβ) protein deposition in the brain |
a. Low CSF Aβ42 |
b. Positive PET amyloid imaging |
(2) Markers of downstream neurodegeneration |
a. Elevated CSF tau (total and phosphorylated) |
b. Decreased metabolism in temporal and parietal cortex on 18flurodeoxyglucose PET |
c. Atrophy on MRI in temporal (medial, basal, and lateral) and medial parietal cortex |
AD, Alzheimer's disease; CSF, cerebrospinal fluid; PET, positron emission tomography.