Table 1

Causes of peripheral nervous system (PNS) vasculitis

A primary immune-mediated vasculitic processANCA associatedWegener's granulomatosis, Churg–Strauss syndrome, polyarteritis nodosa and microscopic polyangiitis
Immune complex drivenHenoch-Schönlein purpura and essential cryoglobulinaemic vasculitis
A vasculitic process resulting from other types of autoimmune conditionsRheumatoid arthritis, systemic sclerosis, Sjögren's syndrome, essential cryoglobulinaemia
A vasculitic process resulting from other non-autoimmune conditionsDiabetesDiabetic radiculoplexus neuropathy
DrugsAmphetamine, propylthiouracil, hydralazine, interferons, non-steroidal anti-inflammatory drugs, penicillin, allopurinol, cocaine, heroin, sulfonamides and phenytoin
Viral infectionsCytomegalovirus, human T-lymphotropic virus 1, hepatitis, human immunodeficiency virus, Herpes simplex virus, Varicella zoster virus, Epstein-Barr virus, cytomegalovirus
Bacterial infectionsInfective endocarditis, Strep pneumoniae, Haemophilus influenzae, Salmonella typhi, alpha haemolytic strep, Lyme, Mycobacterium tuberculosis, leprosy, Treponema pallidum
Fungal infectionsAspergillus, coccidoides, mucormycosis, histoplasma capsulatum
Protozoa infectionsToxoplasma gondii, Plasmodium falciparum
Radiation
Paraneoplastic
Malignancy
Chronic inflammatorySarcoidosis
  • ANCA, antineutrophil cytoplasmic antibody.