Drugs to avoid in patients with Parkinson's disease
| Avoid | Consider instead |
|---|---|
| Antiemetics | |
| Prochlorperazine Chlorpromazine Metoclopramide Cinnarizine Nabilone Hyoscine hydrobromide | Domperidone (please note MHRA advice) Ondansetron (not to be used with apomorphine) Cyclizine |
| Antipsychotics | |
| Amisulpride Chlorpromazine Fluphenazine Haloperidol | Lorazepam and diazepam Sertraline Quetiapine Mirtazapine |
The drugs in the left hand column may worsen the symptoms of Parkinson's disease and increase the risk of neuroleptic malignant-like syndrome because they block dopamine receptors. The drugs in the right hand column are safer alternatives. This is not an exhaustive list and readers should refer to the British National Formulary or a pharmacist. MHRA, Medical and Healthcare products Regulatory Agency