Effect of mechanical thrombectomy compared with best medical therapy on good functional outcome (modified Rankin Score≤2* at 90 days)
| Trial | Mechanical thrombectomy | Best medical therapy | Adjusted OR (95% CI) p value |
| MR CLEAN35 | 76 (32.6) | 51 (19.1) | 2.16 (1.39–3.38) |
| REVASCAT36 | 45 (43.7) | 29 (28.2) | 2.1 (1.1–4.0) |
| EXTEND 1A37 | 25 (71) | 14 (40) | 4.2 (1.4–12) p=0.01 |
| SWIFT-prime38 | 59 (60) | 33 (35) | 1.70 (1.23–2.33) p<0.001 |
| ESCAPE39 | 87 (53.0) | 43 (29.3) | 1.7 (1.3–2.2) |
| THRACE40 | 106 (53) | 85 (42) | 1.55 (1.05–2.30) p=0.028† |
| THERAPY41 | 19 (38) | 14 (30) | 1.4 (0.60–3.3) p=0.55 |
| PISTE42 | 17 (57) | 10 (35) | 4.92 (1.23–19.69) p=0.021‡ |
| EASI43 | 20 (50)§ | 14 (38)¶ | p=0.36 |
Figures are numbers of patients achieving a good functional outcome at 90 days after stroke (%).
*This corresponds to slight or no residual disability as a result of the stroke.
†Value at 30 days.
‡Per protocol population analysis.
§19/35 anterior circulation, 1/5 posterior circulation.
¶14/32 anterior circulation, 0/5 posterior circulation.
OR = odds ratio.