Sensitivity of CSF RT-QuIC in different sCJD subtypes
| sCJD subtype | Sensitivity (%) First-generation RT-QuIC12 (total number cases investigated) | Sensitivity (%) Second-generation RT-QuIC16 (total number cases investigated) |
| MM1/MV1 | 89 (111) | 96 (119) |
| MV2 | 81 (26) | 89 (9) |
| MM2 | 42 (10) | 78 (9) |
| VV1 | 100 (1) | 75 (8) |
| VV2 | 78 (27) | 100 (27) |
CSF, cerebrospinal fluid; MM, methionine; MV, methionine and valine; RT-QuIC, real-time quaking-induced conversion; sCJD, sporadic Creutzfeldt-Jakob disease;VV, valine.