Recommended treatment for neuroborreliosis2
| Symptoms | First-line treatment | Second-line/alternative |
| Neuroborreliosis affecting the cranial nerves or peripheral nervous system | Oral doxycycline 100 mg twice daily or 200 mg daily for 21 days | Amoxicillin 1 g three times daily for 21 days |
| Neuroborreliosis affecting the CNS* | Intravenous ceftriaxone 2 g twice daily or 4 g daily for 21 days (consider switching to oral doxycycline when the patient is well) | Doxycycline 200 mg twice daily or 400 mg daily for 21 days |
*Central nervous system parenchymal involvement such as myelitis, encephalitis or vascular events.