Table 1

Recommended treatment for neuroborreliosis2

SymptomsFirst-line treatmentSecond-line/alternative
Neuroborreliosis affecting the cranial nerves or peripheral nervous systemOral doxycycline 100 mg twice daily or 200 mg daily for 21 daysAmoxicillin 1 g three times daily for 21 days
Neuroborreliosis affecting the CNS*Intravenous ceftriaxone 2 g twice daily or 4 g daily for 21 days (consider switching to oral doxycycline when the patient is well)Doxycycline 200 mg twice daily or 400 mg daily for 21 days
  • *Central nervous system parenchymal involvement such as myelitis, encephalitis or vascular events.