Parkinsonism-hyperpyrexia syndrome | Serotonin syndrome |
Muscle rigidity, prominent akinesia | Tremor, myoclonus, akathisia, hypertonicity |
Altered mental status Hyperthermia Rhabdomyolysis | |
Trigger factors | |
Infection, trauma, medication changes | Drug combinations: MAO inhibitor, SSRI, tricyclic antidepressant, opioids |
Treatment | |
Escalating dopaminergic treatment | Stopping the causative drug |
Supportive intensive care management |
MAO, monoamine oxidase B; SSRI, selective-serotonin reuptake inhibitor.