Comparison of triptans in acute cluster headache treatment
| Triptan | Efficacy | Cost (as per BNF April 2019) |
| Subcutaneous sumatriptan 6 mg | Headache relief rates at 15 min: placebo 26% and sumatriptan injection 74%19 | Imigran £50.96 for two injections Generic £39.50 for two injections |
| Sumatriptan nasal spray 20 mg | Pain-free rates at 30 min: placebo 18% and sumatriptan nasal spray 47%24 | Imigran £14.16 for two or £42.47 for six |
| Zolmitriptan nasal spray 5 mg and 10 mg | Headache relief rates at 30 min (defined as reduction in pain severity): placebo 21%; zolmitriptan nasal spray 5 mg 40% and zolmitriptan nasal spray 10 mg 62%23 | Zomig 5 mg/0.1 mL nasal spray 0.1 mL unit dose- £36.50 for six 10 mg formulation—not available. |