Appropriate indications | Inappropriate indications |
---|---|
Persistent or progressive unexplained mild cognitive impairment | Typical AD presentation with a typical age of onset (>65 years) |
Dementia with atypical clinical course or aetiologically mixed presentation | To determine dementia severity |
Dementia with early age of onset (<65 years) | Solely based on a positive family history of dementia or presence of APOE4 |
Cognitive complaint that is unconfirmed on clinical examination (subjective cognitive impairment) | |
In lieu of genotyping for suspected autosomal mutation carriers | |
In asymptomatic people | |
Non-medical use (eg, legal, insurance coverage or employment screening) |
AD, Alzheimer’s disease; APOE4, apolipoprotein E4; PET, positron emission tomography.