Table 1

Evidence base for the efficacy of peripheral nerve block in treating different headache disorders

Headache disorderType of nerve block studiedEvidence level*
Acute migraineGON2B8
Chronic migraineGON2A9 10
Cluster headacheGON, suboccipital1B11 12
Occipital neuralgiaGON2B13
Chronic daily headacheGON2B14
Other trigeminal autonomic cephalalgias
SUNCT/SUNASupraorbital, supratrochlear45
Paroxysmal hemicrania/hemicrania continuaSupraorbital, supratrochlear415
Other painful cranial neuralgiasSupraorbital, auriculotemporal416 17
  • *Based on the Oxford Centre for Evidence-based Medicine Levels of Evidence.

  • GON, greater occipital nerve; SUNCT, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing; SUNA, short-lasting unilateral neuralgiform headache attacks with cranial autonomic features.