Symptoms and signs of PSP
| Symptoms | Signs |
| Cognitive change (apathy, impulsivity) | Akinetic rigidity—neck and axial rigidity >limbs ‘sniffing morning breeze sign’ |
| Impaired balance | Slow saccades and ‘round the houses’ vertical saccades |
| Early falls (with increased fracture risk) | Vertical supranuclear gaze palsy |
| Blurry or double vision | Frontalis overactivity, reduced blink, staring expression |
| Sleep difficulties | Tendency to lose balance spontaneously or on the ‘pull test’ |
| Dysphagia (especially liquids) | Uncontrolled decent into a chair |
| Drooling, sialorrhoea | Dystonia, cervical, axial >limbs |
| Urinary urgency or incontinence | Apraxia (CBS overlap) |
| Constipation | Emotional lability (pseudobulbar affect) |
| Depression or anxiety | Reduced verbal fluency |
| Hyperphagia and change in food preferences | Dysarthrophonia |
| Weight loss (with possible malnutrition) |
CBS, corticobasal syndrome; PSP, progressive supranuclear palsy.