Differential diagnosis for progressive supranuclear palsy other than Parkinson's disease.
Disease | Clues to diagnosis |
| CBS | Early asymmetric akinesia, apraxia, dystonia, myoclonus |
| MSA | Predominant autonomic features, cerebellar signs |
| FTD | Predominant behaviour features, marked atrophy |
| NPH | Supportive imaging findings |
| Vascular disease | Supportive imaging findings, vascular risk factors |
| Structural lesion | Supportive imaging findings |
| Rare genetic mimics | Young age of symptom onset, relevant family history |
| DLB | Hallucinations and fluctuations common |
| AD | Disproportionate memory impairment, hippocampal atrophy on MRI, suggestive CSF biomarkers |
These differential diagnoses may cause abnormal eye signs, but lack the distinctive selective vertical gaze palsy and slowing of PSP and the other characteristic clinical face and limb signs of PSP.
AD, Alzheimer's disease ; CBS, corticobasal syndrome; DLB, Dementia with Lewy bodies ; FTD, Frontotemporal dementia ; MSA, Multiple System Atrophy ; NPH, Normal Pressure Hydrocephalus ; PSP, progressive supranuclear palsy.