Typical characteristics in patients with individual nodal/paranodal antibodies
| Characteristics | Nodal/paranodal antibody | |||
| NF155 | Pan-NF | CNTN1 | Caspr1 or CNTN1:Caspr1 complex | |
| Clinical features | ||||
| Neuropathy | Severe non-length-dependent sensorimotor neuropathy | |||
| Age (median; years) | 51.5 | 57.4 | 60 | 57.5 |
| Male:female | 1.6:1 | 3.5:1 | 3.3:1 | 2.3:1 |
| Initial diagnosis GBS | ||||
| Ataxia | ||||
| Tremor | ||||
| Pain | ||||
| Cranial nerve palsies | ||||
| Respiratory failure | ||||
| Autonomic dysfunction | ||||
| Nerve root abnormalities | ‡ | |||
| Associated disorders | ||||
| Nephrotic syndrome (MGN–CNTN1, FSGS–pan-NF) | § | † | ||
| IgG lymphoproliferative disorder | ||||
| CCPD | * | |||
| Key | ||||
| Absent | ||||
| + | <25% | |||
| ++ | 25%–50% | |||
| +++ | 50%–75% | |||
| ++++ | 75%–100% | |||
Coloured boxes indicate frequency (as per key) of characteristic from our cohort.
*18 40
†7–10 12
‡17
§1
Caspr1, contactin-associated protein-1; CCPD, combined central and peripheral demyelination; CN, cranial nerve; CNTN1, contactin-1; FSGS, focal segmental glomerulosclerosis; GBS, Guillain-Barré syndrome; IgG, immunoglobulin G; MGN, membranous glomerulonephritis; NF155, neurofascin 155.