Author | Comparative measure | Preconception | Trimester 1 | Trimester 2 | Trimester 3 | Post partum (time of sample) |
Pennell et al 66 | Increase in clearance cf preconception | 91% (±107%) | 149% (±142%) | 261% (±194%) | 50%±69% | |
Fotopoulou et al 67 | Median ratio lamotrigine dose:serum (1st and 3rd quartiles) | 39 (39–41) | 77 (68–154) | 92 (76–167) | 97 (74–110) | 35 (35–36) (at 3 weeks) |
Petrenaite et al 68 | Mean ratio serum lamotrigine: dose | 63.5±30.8 | 46.7±18.3 | 22.1±5.4 | 21.7±7.1 | 70±10 (at 6 weeks) |
de Haan et al 69 | Mean ratio serum lamotrigine concentration to dose (as percentage of preconception baseline) | 82%±14% | 51%±14% | 97%±15% | 48%±10% | |
Öhman et al 70 | Mean ratio lamotrigine dose:plasma | 227±74 | 66.5±17.9 |