Table 6

Therapeutic drug monitoring during pregnancy—advantages and disadvantages

AdvantagesDisadvantages
Anticipates falling concentrations and increases treatment pre-emptively.Increases drug load even in patients with well-controlled epilepsy.
Better seizure control.Increases cost and inconvenience of pregnancy care.
Reduced risks of maternal harm.Maintains relatively higher degree of fetal exposure to antiseizure medications.
Reduced risks to fetus from seizures.Unpredictability of pregnancy-related pharmacokinetic change means monitoring may not pick up changes in level.
Delay in receiving results of testing (up to 6 weeks in some situations) means monitoring may not pick up changes in serum concentration.