Table 1

Ganglioside autoantibody associations with inflammatory neuropathies

NeuropathyChronicityMain featuresAntibodiesImmunoglobulin class
AMANAcutePure motorGM1, GD1aIgG
Miller Fisher syndromeAcuteAtaxia, ophthalmoplegiaGQ1b, GT1aIgG
Acute sensory ataxic neuropathyAcuteSensory, ataxiaGD1b or GQ1bIgG
Pharyngeal–cervical–brachial weaknessAcuteOropharyngeal, neck and shoulder weaknessGT1a>GQ1bIgG
MMNCBChronicMotor, asymmetrical upper limb predominantGM1, complex GM1:GalCIgM
CANOMAD, CANDAChronicSensory ataxicGD3, GD1B, GT1b, GQ1b (disialosyl antibodies)IgM
  • Adapted from Delmont et al.19

  • AMAN, acute motor axonal neuropathy; CANDA, chronic ataxic neuropathy with disialosyl antibodies; CANOMAD, chronic ataxic neuropathy with ophthalmoplegia, IgM paraprotein and anti-disialosyl antibodies; GM:GalC, complex of GM1 and galactocerebroside; MMNCB, multifocal motor neuropathy with conduction block.