Summary of case series/cohort studies in neurological disorders containing a minimum of five patients
| Paper | Population | Patient details | Pregnancy outcomes | MS/NMO outcomes |
| Seyed Ahadi et al 48 | NMOSD; RTX only | 8 patients, exposure within 6M 2 treated during pregnancy (17/40, 30/40) | 2 elective terminations (5/40 and 8/40) 1 stillbirth at 36/40 (nuchal cord) | Relapse free |
| Seyed Ahadi et al 49 | MS; RTX only | 21 patients, median time from RTX to pregnancy 7M (SD 5M) 1 treated in pregnancy, 2 ongoing | 10 live births–1 preterm birth 7 elective terminations, 2 T1 miscarriages | Relapse free |
| Kim et al 50 | NMOSD; RTX only | 11 women/15 pregnancies; median time from RTX to pregnancy 3M ; 1 T1 exposure | 11 live births 1 elective abortion, 3 T1 miscarriages | 1 relapse in pregnancy, same patient had PP relapse |
| Kümpfel et al 19 | MS, NMOSD, other neuroinflammation; RTX and OCR | 81 women/88 pregnancies/67 included All treated within 12M of pregnancy | 60/68 - live birth (1 twin), 9 premature 5 miscarriages; 2 MCM- VSD, ASD with pulmonary stenosis | Relapse free in pregnancy 5/29 relapse PP |
| Das et al 22 | MS and NMOSD; RTX only | 11 pregnancies, 10 within 6M RTX | All term births, healthy children | Relapse free in pregnancy 1 relapse PP |
| Dobson et al 14 | MS; OCR only | 1223 pregnancies, 414 exposure within 3M, 128 with T1 exposure 604 known outcomes | Where OCR used within 3M of conception: 171 live births 20 elective terminations, 29 miscarriages 4 stillbirths, 2 ectopic pregnancies; 7/604 MCM | Not reported |
| Hellwig et al | MS; Ofatumamab | 32 pregnancies, 4 exposure within 6M 12 with T1 exposure | 23 known outcomes: 11 live births, 6 miscarriages, 6 elective terminations | Not reported |
| Razaz et al 51 | MS; RTX only | 76 suspended RTX for pregnancy | Not reported | 1 pregnancy relapse in T1 1 patient with gad lesion PP |
| Smith et al 17 | MS; RTX only | 55 women/74 pregnancies 50 within 6M of RTX, 9 T1 exposure | 38 live births (37 pregnancies); 4 preterm births (1 twins) 23 T1 miscarriages, 1 neonatal death (27/40 twin), 1 perinatal stroke | 1 relapse in pregnancy 1 relapse PP |
ASD, atrial septal defect ; MCM, Major congenital malformation ; MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorder ; OCR, ocrelizumab; PP, post partum ; RTX, Rituximab ; VSD, Ventricular septal defect .