Table 3

Exclusion criteria6

Exclusion criteriaClinically established/ probable MSAPossible prodromal MSADifferential
Substantial and persistent beneficial response to dopaminergic medicationsParkinson’s disease
Unexplained anosmia on olfactory testing
Fluctuating cognition with pronounced variation in attention and alertness and early decline in visuo-perceptual abilitiesDementia with Lewy bodies
Recurrent visual hallucinations not induced by drugs within 3 years of disease onset
DSM-V Dementia within 3 years of disease onsetDementia with Lewy bodies
Progressive supranuclear palsy
Corticobasal degeneration
Downgaze supranuclear palsy/slowing of vertical saccadesProgressive supranuclear palsy
Brain MRI findings suggesting an alternative diagnosis (eg, progressive supranuclear palsy, multiple sclerosis, vascular parkinsonism, symptomatic cerebellar disease)
Documentation of an alternative condition (MSA look-alike, including genetic or symptomatic ataxia and parkinsonism) known to produce similar symptoms and plausibly connected
  • DSM-V, Diagnostic and Statistical Manual of Mental Disorders; MSA, multiple system atrophy.