Table 14

Immunosuppressant dose adjustment in chronic renal impairment

DrugAccumulates in chronic renal impairmentPotential for nephrotoxicityChronic renal impairment (GFR, mL/min/1.73 m2)
Stage III (30–59)Stage IV (15–29)Stage V (<15)
Adjustment (% of standard dose)
MMFYesNoNormal1 mg two times per day max1 mg two times per day max
CYCYesYesAccording to age and serum creatinine (table 13)
  • AZA, azathioprine; CYC, cyclophosphamide; GFR, glomerular filtration rate; MMF, mycophenolate mofetil; MTX, methotrexate.