References
Cairns NJ, Neumann M, Bigio EH et al (2007) TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol 171:227–240
Davidson Y, Kelley T, Mackenzie IRA et al (2007) Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43. Acta Neuropathol 113:521–533
Dickson DW (2008) TDP-43 immunoreactivity in neurodegenerative disorders: disease versus mechanism specificity. Acta Neuropathol 115:147–149
Forman MS, Mackenzie IR, Cairns NJ et al (2006) Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol 65:571–581
Geser F, Martinez-Lage M, Robinson J et al (2009) Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Arch Neurol 66:180–189
Josephs KA, Stroh A, Dugger B, Dickson DW (2009) Evaluation of subcortical pathology and clinical correlations in FTLD-U. Acta Neuropathol 118:349–358
Mackenzie IRA, Baborie A, Pickering-Brown S et al (2006) Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype. Acta Neuropathol 112:539–549
Mackenzie IR, Neumann M, Bigio EH et al (2009) Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol 117:15–18
Neumann M, Mackenzie IR, Cairns NJ et al (2007) TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 66:152–157
Neumann M, Sampathu DM, Kwong LK et al (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314:130–133
Sampathu DM, Neumann M, Kwong LK et al (2006) Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. Am J Pathol 169:1343–1352
Acknowledgments
The authors wish to thank their clinical colleagues, in particular Dr. William Seeley (University of California San Francisco), for their support and encouragement in moving this endeavour forward. Studies reviewed here from the Center for Neurodegenerative Disease Research were supported by AG-10124 and AG-17586.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mackenzie, I.R.A., Neumann, M., Baborie, A. et al. A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol 122, 111–113 (2011). https://doi.org/10.1007/s00401-011-0845-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00401-011-0845-8