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Cognitive impairment after cerebral venous thrombosis: a two-center study

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Abstract

The objective of this observational study of consecutive patients hospitalized for cerebral venous thrombosis (CVT) was to determine the prevalence of post-CVT cognitive impairment and identify factors associated with this condition. Out of a total of 73 patients hospitalized for CVT, 52 were included in the study and 44 were assessed with a comprehensive neuropsychological battery. At the last outpatient visit (mean ± SD time since CVT: 22 ± 13 months), a standardized, neuropsychological assessment was administered. Cognitive impairment was defined as significant impairment (with a cut-off at the 5th percentile) in at least two of the cognitive domains tested in the neuropsychological battery or severe aphasia or cognitive disorders with MMSE score ≤17 out of 30. Cognitive impairment was observed in 16 patients (31 %; 95 % CI 18–43 %): 4 with major disability precluding comprehensive assessment (3 with severe aphasia, 1 with MMSE ≤17) and 12 with significant impairments in at least two cognitive domains. Determinants of long-term cognitive impairment were straight sinus involvement (OR 22.4; 95 % CI 1.79–278.95; p = 0.016) and the presence of parenchymal lesions on follow-up magnetic resonance imaging (OR 7.8; 95 % CI 1.40–43.04; p = 0.019). The sole predictor of failure to return to full-time employment was cognitive impairment (OR 21.0; 95 % CI 3.35–131.44; p = 0.001). Cognitive impairment persists in up to one-third of cases of CVT. It is more frequent in patients with deep CVT and persistent parenchymal lesions and is associated with failure to return to full-time employment.

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Conflicts of interest

The authors have no conflict of interest related to this study to declare.

Ethical standard

This study has been approved by the appropriate ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

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Authors and Affiliations

  1. Department of Neurology, Amiens University Hospital, Amiens, France

    Jean-Marc Bugnicourt, Martine Roussel, Sandrine Canaple, Chantal Lamy, Claire Leclercq & Olivier Godefroy

  2. Laboratory of Functional Neurosciences and Pathology (EA 4559), Jules Verne University of Picardie, Amiens, France

    Jean-Marc Bugnicourt, Claire Leclercq & Olivier Godefroy

  3. INSERM U1088, Amiens, France

    Jean-Marc Bugnicourt

  4. Department of Neurology, Rouen University Medical Center, Rouen, France

    Evelyne Guegan-Massardier, Olivier Martinaud, Aude Triquenot-Bagan, David Wallon & Didier Hannequin

  5. Service de Neurologie, CHU Amiens, Place Victor Pauchet, 80054, Amiens Cedex 1, France

    Jean-Marc Bugnicourt

Authors
  1. Jean-Marc Bugnicourt
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  2. Evelyne Guegan-Massardier
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  3. Martine Roussel
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  4. Olivier Martinaud
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  5. Sandrine Canaple
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Correspondence to Jean-Marc Bugnicourt.

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Bugnicourt, JM., Guegan-Massardier, E., Roussel, M. et al. Cognitive impairment after cerebral venous thrombosis: a two-center study. J Neurol 260, 1324–1331 (2013). https://doi.org/10.1007/s00415-012-6799-5

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  • DOI: https://doi.org/10.1007/s00415-012-6799-5

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