Size and composition of the calf and quadriceps muscles in Duchenne muscular dystrophy: A tomographic and histochemical study☆
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Assessing drug effect from distributional data: A population approach with application to Duchenne Muscular Dystrophy treatment
2019, Computer Methods and Programs in BiomedicineIn Vivo Viscoelastic Response (VisR) Ultrasound for Characterizing Mechanical Anisotropy in Lower-Limb Skeletal Muscles of Boys with and without Duchenne Muscular Dystrophy
2018, Ultrasound in Medicine and BiologyCitation Excerpt :Similarly, Hollingsworth et al. (2013), in an MRI-based study of boys with DMD, found that the RF rapidly increased in fatty content in the age range 7–10 y, whereas the GM remained relatively unchanged. Instead of fatty and fibrous changes, the GM undergoes primarily inflammation and hypertrophy in the age range of the boys included in this study (Jones et al. 1983; Kornegay et al. 2003; Torriani et al. 2012). Interestingly, although hypertrophy increases the size of the GM, VisR does not detect an associated change in elastic anisotropy.
Diaphragm: A vital respiratory muscle in mammals
2016, Annals of AnatomyCitation Excerpt :In these patients, muscle hypertrophy is attributed to the deposition of fat and connective tissue, and is thus named pseudo-hypertrophy. However, some imaging studies have demonstrated true hypertrophy in some individuals (Jones et al., 1983; Cros et al., 1989; Kornegay et al., 2012). DMD has been described as the most severe and common X-linked disorder, affecting 1 in 3500 male births (Nakamura and Takeda, 2011).
Calf muscle involvement in Becker muscular dystrophy: When size does not matter
2014, Journal of the Neurological SciencesCitation Excerpt :Calf hypertrophy has been considered as a typical, although not specific, feature of dystrophinopathies since their first description: the classical definition used by Duchenne was “pseudo-hypertrophic muscular paralysis” [6], conveying the concept that this paradoxical muscle enlargement was related to deposition of fat and connective tissue. This concept was later supported by pathology studies [7,8], but the composition of enlarged calf muscles is still somehow controversial. We used an objective radiological measure of muscle size based on MR imaging, and the results obtained with our approach confirm those obtained by previous radiological studies, performed using non-MR techniques and on a limited number of patients [9,10].
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The authors are grateful to the Muscular Dystrophy Group of Great Britain for their financial support.